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Magnetic stimulation supports muscle and nerve regeneration after trauma in mice


Stölting, Meline N L; Arnold, Anne Sophie; Haralampieva, Deana; Handschin, Christoph; Sulser, Tullio; Eberli, Daniel (2016). Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle & Nerve, 53(4):598-607.

Abstract

INTRODUCTION Magnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined. METHODS Muscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor-units, post-trauma muscle/nerve regeneration, and vascularization was investigated. RESULTS We found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids post-trauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma. DISCUSSION Our results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of NMJs. This article is protected by copyright. All rights reserved.

Abstract

INTRODUCTION Magnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined. METHODS Muscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor-units, post-trauma muscle/nerve regeneration, and vascularization was investigated. RESULTS We found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids post-trauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma. DISCUSSION Our results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of NMJs. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:29 Oct 2015 11:13
Last Modified:05 Apr 2016 19:27
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0148-639X
Publisher DOI:https://doi.org/10.1002/mus.24780
PubMed ID:26202157

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