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Behavioural changes in mothers and maternally sensitised female mice


Szabó, Éva R; Dobolyi, Árpád; Gévai, Lőrinc; Simon, László; Lutz, Thomas A; Cservenák, Melinda; Endrényi, Miklós (2015). Behavioural changes in mothers and maternally sensitised female mice. Behaviour, 152(12-13):1801-1819.

Abstract

The maternal motivation and depression-like behaviour of primiparous mother and maternally sensitised virgin female mice were investigated. During a 1-h test period, dams and sensitised female mice spent significantly more time in pup-associated than in control cages when they could freely choose between them, while virgin control and ovariectomised females had no such preference. In the forced swim test, the time spent in active (swimming and struggling) and passive (floating) behaviours was measured for 6 min. Mother mice spent more time engaged in active behaviours than virgin and sensitised female mice, while the latter two groups did not differ from each other in the forced swim test. The results suggest that maternal motivation is increased in postpartum mothers and maternally sensitised female mice.We also provide the first demonstration that postpartum mother mice display anti-depression-like behaviours in the forced swim test, while maternally sensitised females do not show such emotional changes.

Abstract

The maternal motivation and depression-like behaviour of primiparous mother and maternally sensitised virgin female mice were investigated. During a 1-h test period, dams and sensitised female mice spent significantly more time in pup-associated than in control cages when they could freely choose between them, while virgin control and ovariectomised females had no such preference. In the forced swim test, the time spent in active (swimming and struggling) and passive (floating) behaviours was measured for 6 min. Mother mice spent more time engaged in active behaviours than virgin and sensitised female mice, while the latter two groups did not differ from each other in the forced swim test. The results suggest that maternal motivation is increased in postpartum mothers and maternally sensitised female mice.We also provide the first demonstration that postpartum mother mice display anti-depression-like behaviours in the forced swim test, while maternally sensitised females do not show such emotional changes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:evaluation of laboratory animal tracking; sensitised behaviour; pup-induced conditioned place preference; maternal motivation; postpartum depression; forced swim test; mouse dams
Language:English
Date:2015
Deposited On:30 Oct 2015 07:52
Last Modified:05 Apr 2016 19:28
Publisher:Brill Academic Publishers
ISSN:0005-7959
Publisher DOI:https://doi.org/10.1163/1568539X-00003305

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