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Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase


Hammock, B D; Pinot, F; Beetham, J K; Grant, D F; Arand, M E; Oesch, F (1994). Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase. Biochemical and Biophysical Research Communications, 198(3):850-856.

Abstract

A putative covalent, alpha-hydroxyacyl intermediate was isolated by the brief exposure of murine soluble epoxide hydrolase to its substrate. The reaction was reversed by time and blocked by competitive inhibitors. The formation of the intermediate was dependent upon the concentration of the enzyme and was increased by incubation under acidic conditions. The structure of the intermediate was supported by microchemical methods.

Abstract

A putative covalent, alpha-hydroxyacyl intermediate was isolated by the brief exposure of murine soluble epoxide hydrolase to its substrate. The reaction was reversed by time and blocked by competitive inhibitors. The formation of the intermediate was dependent upon the concentration of the enzyme and was increased by incubation under acidic conditions. The structure of the intermediate was supported by microchemical methods.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:15 February 1994
Deposited On:29 Oct 2015 11:48
Last Modified:05 Apr 2016 19:29
Publisher:Elsevier
ISSN:0006-291X
Publisher DOI:https://doi.org/10.1006/bbrc.1994.1121
PubMed ID:8117289

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