Header

UZH-Logo

Maintenance Infos

Functional evidence for continued alveolarisation in former preterms at school age?


Yammine, Sophie; Schmidt, Anne; Sutter, Oliver; Fouzas, Sotirios; Singer, Florian; Frey, Urs; Latzin, Philipp (2016). Functional evidence for continued alveolarisation in former preterms at school age? European Respiratory Journal, 47:147-155.

Abstract

Prematurity is the most common disruptor of lung development. The aim of our study was to examine the function of the more vulnerable peripheral airways in former preterm children by multiplebreath washout (MBW) measurements. 86 school-aged children, born between 24 and 35 weeks of gestation and 49 term-born children performed nitrogen MBW. Lung clearance index (LCI), and slope III-derived Scond and Sacin were assessed as markers for global, convection-dependent and diffusion–convection-dependent ventilation inhomogeneity, respectively.
We analysed the data of 77 former preterm (mean (range) age 9.5 (7.2–12.8) years) and 46 term-born children (mean age 9.9 (6.0–15.9) years). LCI and Sacin did not differ between preterm and term-born children. Scond was significantly elevated in preterm compared to term-born participants (mean difference z-score 1.74, 95% CI 1.17–2.30; p<0.001), with 54% of former preterm children showing elevated Scond. In multivariable regression analysis Scond was significantly related only to gestational age (R2=0.37). Normal Sacin provides evidence for a functionally normal alveolar compartment, while elevated Scond indicates impaired function of more proximal conducting airways. Together, our findings support the concept of continued alveolarisation, albeit with “dysanaptic” lung growth in former preterm children.

Abstract

Prematurity is the most common disruptor of lung development. The aim of our study was to examine the function of the more vulnerable peripheral airways in former preterm children by multiplebreath washout (MBW) measurements. 86 school-aged children, born between 24 and 35 weeks of gestation and 49 term-born children performed nitrogen MBW. Lung clearance index (LCI), and slope III-derived Scond and Sacin were assessed as markers for global, convection-dependent and diffusion–convection-dependent ventilation inhomogeneity, respectively.
We analysed the data of 77 former preterm (mean (range) age 9.5 (7.2–12.8) years) and 46 term-born children (mean age 9.9 (6.0–15.9) years). LCI and Sacin did not differ between preterm and term-born children. Scond was significantly elevated in preterm compared to term-born participants (mean difference z-score 1.74, 95% CI 1.17–2.30; p<0.001), with 54% of former preterm children showing elevated Scond. In multivariable regression analysis Scond was significantly related only to gestational age (R2=0.37). Normal Sacin provides evidence for a functionally normal alveolar compartment, while elevated Scond indicates impaired function of more proximal conducting airways. Together, our findings support the concept of continued alveolarisation, albeit with “dysanaptic” lung growth in former preterm children.

Statistics

Citations

2 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 11 Nov 2015
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2016
Deposited On:11 Nov 2015 13:14
Last Modified:05 Apr 2016 19:30
Publisher:European Respiratory Society
ISSN:0903-1936
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1183/13993003.00478-2015
PubMed ID:26493788

Download

Preview Icon on Download
Content: Published Version
Filetype: PDF - Registered users only
Size: 355kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations