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Fluorescent molecular tomography for in vivo imaging of mouse atherosclerosis


Arranz, Alicia; Rudin, Markus; Zaragoza, Carlos; Ripoll, Jorge (2015). Fluorescent molecular tomography for in vivo imaging of mouse atherosclerosis. In: Andrés, Vicente; Dorado, Beatriz. Methods in Mouse Atherosclerosis. New York: Springer, 367-376.

Abstract

Optical imaging technologies such as fluorescence molecular tomography (FMT) are gaining great relevance in cardiovascular research. The main reason is the increased number of available fluorescent agents, especially those termed “activatable probes,” which remain quenched under baseline conditions and are fluorescent when a specific enzymatic activity is present. A major characteristic of FMT is the possibility of obtaining quantitative data of fluorescence signal distribution in a noninvasive fashion and using nonionizing radiation, making FMT an invaluable tool for longitudinal studies with biomedical applications. Here, we describe a standard procedure to perform FMT experiments in atherosclerosis mouse models, from the handling of the animals to the reconstruction of the 3D images.

Abstract

Optical imaging technologies such as fluorescence molecular tomography (FMT) are gaining great relevance in cardiovascular research. The main reason is the increased number of available fluorescent agents, especially those termed “activatable probes,” which remain quenched under baseline conditions and are fluorescent when a specific enzymatic activity is present. A major characteristic of FMT is the possibility of obtaining quantitative data of fluorescence signal distribution in a noninvasive fashion and using nonionizing radiation, making FMT an invaluable tool for longitudinal studies with biomedical applications. Here, we describe a standard procedure to perform FMT experiments in atherosclerosis mouse models, from the handling of the animals to the reconstruction of the 3D images.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2015
Deposited On:13 Nov 2015 13:31
Last Modified:05 Apr 2016 19:31
Publisher:Springer
Number:1339
ISSN:1064-3745
ISBN:978-1-4939-2928-3
Publisher DOI:https://doi.org/10.1007/978-1-4939-2929-0_27
Related URLs:http://link.springer.com/book/10.1007/978-1-4939-2929-0 (Publisher)

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