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Diminished event-related cortical arousals and altered heart rate response in Parkinson's disease


Sommerauer, Michael; Imbach, Lukas L; Jarallah, Mohan; Baumann, Christian R; Valko, Philipp O (2015). Diminished event-related cortical arousals and altered heart rate response in Parkinson's disease. Movement Disorders, 30(6):866-870.

Abstract

OBJECTIVES: In Parkinson's disease (PD), partial neuronal loss occurs in several arousal-promoting structures, but the effects on arousability have not yet been studied.
METHODS: Polysomnographic analysis of 70 PD patients and 70 control subjects matched for age, sex, body mass index, apnea-hypopnea index (AHI), and periodic limb movements in sleep index (PLMSI).
RESULTS: In PD patients, arousal frequency was diminished by 50% compared with controls (9.1 ± 7.6 vs. 18.6 ± 22.9/h; P < 0.001), and the correlations with AHI (rho = 0.266 vs. 0.503, P = 0.004) and PLMSI (rho = 0.082 vs. 0.354, P = 0.006) were weaker. Hoehn & Yahr stage was an independent negative predictor of arousal index (β = -0.297, P = 0.015). Normalization of heart rate increase after cortical arousals was prolonged in PD patients compared with controls (P = 0.003).
CONCLUSION: Our findings indicate that the neurodegenerative process in PD is associated with an attenuated arousability to respiratory and motor events, and with an alteration of the heart rate pattern accompanying arousals.

Abstract

OBJECTIVES: In Parkinson's disease (PD), partial neuronal loss occurs in several arousal-promoting structures, but the effects on arousability have not yet been studied.
METHODS: Polysomnographic analysis of 70 PD patients and 70 control subjects matched for age, sex, body mass index, apnea-hypopnea index (AHI), and periodic limb movements in sleep index (PLMSI).
RESULTS: In PD patients, arousal frequency was diminished by 50% compared with controls (9.1 ± 7.6 vs. 18.6 ± 22.9/h; P < 0.001), and the correlations with AHI (rho = 0.266 vs. 0.503, P = 0.004) and PLMSI (rho = 0.082 vs. 0.354, P = 0.006) were weaker. Hoehn & Yahr stage was an independent negative predictor of arousal index (β = -0.297, P = 0.015). Normalization of heart rate increase after cortical arousals was prolonged in PD patients compared with controls (P = 0.003).
CONCLUSION: Our findings indicate that the neurodegenerative process in PD is associated with an attenuated arousability to respiratory and motor events, and with an alteration of the heart rate pattern accompanying arousals.

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4 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:May 2015
Deposited On:17 Nov 2015 10:48
Last Modified:05 Apr 2016 19:32
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0885-3185
Publisher DOI:https://doi.org/10.1002/mds.26165
PubMed ID:25736971

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