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Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury


van den Brand, Rubia; Mignardot, Jean-Baptiste; von Zitzewitz, Joachim; Le Goff, Camille; Fumeaux, Nicolas; Wagner, Fabien; Capogrosso, Marco; Martin Moraud, Eduardo; Micera, Silvestro; Schurch, Brigitte; Curt, Armin; Carda, Stefano; Bloch, Jocelyne; Courtine, Grégoire (2015). Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury. Annals of Physical and Rehabilitation Medicine, 58(4):232-237.

Abstract

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients' autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.

Abstract

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients' autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:19 June 2015
Deposited On:23 Nov 2015 14:13
Last Modified:08 Dec 2017 14:57
Publisher:Elsevier
ISSN:1877-0657
Additional Information:Special Issue "Neuromodulation"
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.rehab.2015.04.003
PubMed ID:26100230

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