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Effect of respiratory hyperoxic challenge on magnetic susceptibility in human brain assessed by quantitative susceptibility mapping (QSM)


Özbay, Pinar Senay; Rossi, Cristina; Kocian, Roman; Redle, Manuel; Boss, Andreas; Pruessmann, Klaas Paul; Nanz, Daniel (2015). Effect of respiratory hyperoxic challenge on magnetic susceptibility in human brain assessed by quantitative susceptibility mapping (QSM). NMR in Biomedicine, 28(12):1688-1696.

Abstract

The purpose of this study was to measure the regional change of magnetic susceptibility in human brain upon inhalation of 100% oxygen by MRI quantitative susceptibility mapping (QSM). Fourteen healthy volunteers were scanned in a 3 T MR scanner with a 3D multi-gradient-echo sequence while breathing medical air (normoxia) and pure oxygen (hyperoxia). QSM images and R2 * maps were calculated. Mean susceptibility differences versus white matter were measured in regions of interest covering veins, gray matter (GM), and cerebrospinal fluid (CSF) under both conditions. Hyperoxia resulted in a strong susceptibility decrease in large veins (-154.4 ± 65.9 ppb, p < 10(-6) ), in a smaller reduction in GM (-1.3 ± 1 ppb, p < 0.001), and in a susceptibility increase in ventricular CSF (3.8 ± 1.8 ppb, p < 10(-5) ). The susceptibility decrease in veins implied an increase of venous oxygen saturation (SvO2 ) by 10.1 ± 4.0%. Compared with QSM, R2 * was more seriously affected by long-distance effects not related to local tissue oxygenation and increased in cerebral frontal regions (3 ± 2 s(-1) , p < 0.0004) due to paramagnetic molecular oxygen in cavities. The results highlight the potential of QSM to yield region-specific quantitative oxygenation information, and, thus, for applications such as oxygen-therapy monitoring or identification of hypoxic tumor tissue during radiotherapy planning. Copyright © 2015 John Wiley & Sons, Ltd.

Abstract

The purpose of this study was to measure the regional change of magnetic susceptibility in human brain upon inhalation of 100% oxygen by MRI quantitative susceptibility mapping (QSM). Fourteen healthy volunteers were scanned in a 3 T MR scanner with a 3D multi-gradient-echo sequence while breathing medical air (normoxia) and pure oxygen (hyperoxia). QSM images and R2 * maps were calculated. Mean susceptibility differences versus white matter were measured in regions of interest covering veins, gray matter (GM), and cerebrospinal fluid (CSF) under both conditions. Hyperoxia resulted in a strong susceptibility decrease in large veins (-154.4 ± 65.9 ppb, p < 10(-6) ), in a smaller reduction in GM (-1.3 ± 1 ppb, p < 0.001), and in a susceptibility increase in ventricular CSF (3.8 ± 1.8 ppb, p < 10(-5) ). The susceptibility decrease in veins implied an increase of venous oxygen saturation (SvO2 ) by 10.1 ± 4.0%. Compared with QSM, R2 * was more seriously affected by long-distance effects not related to local tissue oxygenation and increased in cerebral frontal regions (3 ± 2 s(-1) , p < 0.0004) due to paramagnetic molecular oxygen in cavities. The results highlight the potential of QSM to yield region-specific quantitative oxygenation information, and, thus, for applications such as oxygen-therapy monitoring or identification of hypoxic tumor tissue during radiotherapy planning. Copyright © 2015 John Wiley & Sons, Ltd.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:610 Medicine & health
Date:20 October 2015
Deposited On:25 Nov 2015 13:50
Last Modified:05 Apr 2016 19:32
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0952-3480
Publisher DOI:https://doi.org/10.1002/nbm.3433
PubMed ID:26484968

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