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Emerging therapeutic targets for male germ cell tumors


Fankhauser, Christian Daniel; Honecker, Friedemann; Beyer, Jörg; Bode, Peter Karl (2015). Emerging therapeutic targets for male germ cell tumors. Current Oncology Reports, 17(12):54.

Abstract

Male germ cell tumors (GCTs) are curable cancers, yet 10-15 % of patients with metastatic disease fail cisplatin-based first-line treatments. While therapeutic options have increased for various other cancers, little progress has been made in the management of GCT in the last decades. A better understanding of the molecular alterations underlying the disease and identification of new therapeutic targets are needed. Several phase I/II studies with promising new agents are ongoing or have been completed, but most of those trials have been small and have not included translational research. Therefore, molecular profiles predictive for response or new agents have not been identified in male GCT so far. The purpose of this review is to highlight emerging targets and therapies with the potential to improve systemic treatment of metastatic male GCT and to develop strategies for future clinical trials.

Abstract

Male germ cell tumors (GCTs) are curable cancers, yet 10-15 % of patients with metastatic disease fail cisplatin-based first-line treatments. While therapeutic options have increased for various other cancers, little progress has been made in the management of GCT in the last decades. A better understanding of the molecular alterations underlying the disease and identification of new therapeutic targets are needed. Several phase I/II studies with promising new agents are ongoing or have been completed, but most of those trials have been small and have not included translational research. Therefore, molecular profiles predictive for response or new agents have not been identified in male GCT so far. The purpose of this review is to highlight emerging targets and therapies with the potential to improve systemic treatment of metastatic male GCT and to develop strategies for future clinical trials.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Germ cell tumor, Drug therapy, Molecular targeted therapy, Immunotherapy, Novel therapies, Molecular targets
Language:English
Date:December 2015
Deposited On:25 Nov 2015 07:15
Last Modified:05 Apr 2016 19:34
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1523-3790
Additional Information:This article is part of the Topical Collection on Genitourinary Cancers
Publisher DOI:https://doi.org/10.1007/s11912-015-0479-4
PubMed ID:26449842

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