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Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma


Ruf, Melanie; Moch, Holger; Schraml, Peter (2015). Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma. OncoImmunology, 4(12):e1049805.

Abstract

CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.

Abstract

CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2015
Deposited On:26 Nov 2015 11:23
Last Modified:05 Apr 2016 19:34
Publisher:Landes Bioscience
ISSN:2162-4011
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/2162402X.2015.1049805
PubMed ID:26587319

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