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Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model


Muroi, C; Marbacher, Serge; Fandino, J; Keller, Emanuela; Katsunori, Iwasaki; Kenichi, Mishima (2015). Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model. In: Fandino, J; et al. Acta Neurochirurgica Supplement. Springer International Publishing Switzerland: Springer, 315-320.

Abstract

Experiments using genetically engineered mice are regarded as indispensable to gaining a better understanding of the molecular pathophysiology in neuronal injury after subarachnoid hemorrhage (SAH). Therefore, mouse SAH models are becoming increasingly important. The circle of Willis perforation (cWp) model is the most frequently used mouse SAH model. We report and discuss the technical surgical approach, results, and difficulties associated with the cWp model, with reference to the existing literature. Our results largely confirmed previously published results. This model may be the first choice at present, because important pathologies can be reproduced in this model and most findings in the literature are based on it.

Abstract

Experiments using genetically engineered mice are regarded as indispensable to gaining a better understanding of the molecular pathophysiology in neuronal injury after subarachnoid hemorrhage (SAH). Therefore, mouse SAH models are becoming increasingly important. The circle of Willis perforation (cWp) model is the most frequently used mouse SAH model. We report and discuss the technical surgical approach, results, and difficulties associated with the cWp model, with reference to the existing literature. Our results largely confirmed previously published results. This model may be the first choice at present, because important pathologies can be reproduced in this model and most findings in the literature are based on it.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:19 Feb 2016 13:28
Last Modified:08 Dec 2017 15:30
Publisher:Springer
Number:120
ISBN:978-3-319-04980-9
Additional Information:Chapter: Neurovascular Events After Subarachnoid Hemorrhage
Publisher DOI:https://doi.org/10.1007/978-3-319-04981-6_54

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