Header

UZH-Logo

Maintenance Infos

The neural crest: understanding stem cell function in development and disease


Fuchs, Sebastian; Sommer, Lukas (2007). The neural crest: understanding stem cell function in development and disease. Neurodegenerative Diseases, 4(1):6-12.

Abstract

Complex organs like the nervous system are composed of different cell types which are all derived from multipotent stem cells. In vertebrates, a transient population of stem cells, the neural crest, generates the entire peripheral nervous system as well as non-neural progeny. The developmental processes of cellular differentiation and proliferation require precise coordination and control. Errors in the programs that regulate stem cell function can lead to defects that manifest in developmental disorders, in some cases they might even induce cancer. It is therefore of fundamental interest to understand the mechanisms of stem cell maintenance and differentiation. Using the neural crest as a model system helps us not only to understand the role of stem cells in development but might also lead to new aspects for the cure of stem cell-related diseases.

Abstract

Complex organs like the nervous system are composed of different cell types which are all derived from multipotent stem cells. In vertebrates, a transient population of stem cells, the neural crest, generates the entire peripheral nervous system as well as non-neural progeny. The developmental processes of cellular differentiation and proliferation require precise coordination and control. Errors in the programs that regulate stem cell function can lead to defects that manifest in developmental disorders, in some cases they might even induce cancer. It is therefore of fundamental interest to understand the mechanisms of stem cell maintenance and differentiation. Using the neural crest as a model system helps us not only to understand the role of stem cells in development but might also lead to new aspects for the cure of stem cell-related diseases.

Statistics

Citations

12 citations in Web of Science®
12 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

9 downloads since deposited on 14 Dec 2015
7 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2007
Deposited On:14 Dec 2015 14:38
Last Modified:07 Jul 2016 10:07
Publisher:Karger
ISSN:1660-2854
Publisher DOI:https://doi.org/10.1159/000100354
PubMed ID:17429214

Download

Preview Icon on Download
Preview
Content: Published Version
Filetype: PDF
Size: 172kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations