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Generating melanocytes from human pluripotent stem cells


Varum Tavares, Sandra; Sommer, Lukas (2013). Generating melanocytes from human pluripotent stem cells. Pigment Cell & Melanoma Research, 26(5):608-610.

Abstract

Coverage on: Mica, Y., Lee, G., Chambers, S. M., Tomishima, M. J., and Studer, L. (2013). Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCS. Cell Reports 3, 1140-1152. Epidermal melanocytes are pigment-producing cells derived from the neural crest (NC), a transient embryonic stem cell population that emerges from the dorsal margin of the neural plate in vertebrate embryos. The generation of melanocytes encompasses several intricate cellular processes including fate specification, proliferation, migration, and differentiation. Aberrant melanocyte development and homeostasis is at the onset of many pigmentary disorders, such as albinism, piebaldism, vitiligo, hyperplasia, and melanoma. Therefore, understanding human melanocytic development and disease is crucial. To this end, the establishment of methods that facilitate the study of patient-specific melanocyte biology and disease modeling is important.

Abstract

Coverage on: Mica, Y., Lee, G., Chambers, S. M., Tomishima, M. J., and Studer, L. (2013). Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCS. Cell Reports 3, 1140-1152. Epidermal melanocytes are pigment-producing cells derived from the neural crest (NC), a transient embryonic stem cell population that emerges from the dorsal margin of the neural plate in vertebrate embryos. The generation of melanocytes encompasses several intricate cellular processes including fate specification, proliferation, migration, and differentiation. Aberrant melanocyte development and homeostasis is at the onset of many pigmentary disorders, such as albinism, piebaldism, vitiligo, hyperplasia, and melanoma. Therefore, understanding human melanocytic development and disease is crucial. To this end, the establishment of methods that facilitate the study of patient-specific melanocyte biology and disease modeling is important.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:19 September 2013
Deposited On:14 Dec 2015 15:04
Last Modified:05 Apr 2016 19:38
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1755-1471
Publisher DOI:https://doi.org/10.1111/pcmr.12145
PubMed ID:23866058

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