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No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy


Valko, P O; Khatami, R; Baumann, C R; Bassetti, C L (2008). No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy. Journal of Neurology, 255(12):1900-1903.

Abstract

We report on four patients with narcolepsy with cataplexy (NC), who were treated with high-dose intravenous immunoglobulins (IVIg). Although in some patients transient effects were seen of both objective (multiple sleep latency test and maintenance of wakefulness test) and subjective symptoms (Epworth Sleepiness Scale and frequency of cataplexy), these effects lasted at the most for a few weeks and did not persist. Our report challenges the recent observations of a favorable and persistent effect of IVIg in NC patients.

Abstract

We report on four patients with narcolepsy with cataplexy (NC), who were treated with high-dose intravenous immunoglobulins (IVIg). Although in some patients transient effects were seen of both objective (multiple sleep latency test and maintenance of wakefulness test) and subjective symptoms (Epworth Sleepiness Scale and frequency of cataplexy), these effects lasted at the most for a few weeks and did not persist. Our report challenges the recent observations of a favorable and persistent effect of IVIg in NC patients.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2008
Deposited On:15 Jun 2009 07:17
Last Modified:06 Dec 2017 17:23
Publisher:Springer
ISSN:0340-5354
Publisher DOI:https://doi.org/10.1007/s00415-008-0996-2
PubMed ID:18825431

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