Header

UZH-Logo

Maintenance Infos

Hedgehog signaling in basal cell carcinoma


Otsuka, Atsushi; Levesque, Mitchell P; Dummer, Reinhard; Kabashima, Kenji (2015). Hedgehog signaling in basal cell carcinoma. Journal of Dermatological Science, 78(2):95-100.

Abstract

Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with deep invasion, destruction of adjacent structures, recurrence and, on very rare occasions, regional and distant metastases. Mutations that occur in BCC in hedgehog (Hh) pathway genes primarily involve the genes encoding patched homolog (PTCH) and smoothened homolog (SMO). Several animal models have demonstrated the functional relevance of genetic alterations in the Hh pathway during tumorigenesis. Recently, targeted therapy has become available both commercially and in the context of human clinical trials. Interestingly, Hh pathway inhibitors not only suppress BCC progression but also promote acquired immune responses. Since immune responses are crucial for long-term tumor control, new clinical trials, such as those involving a combination of Hh inhibitors with immune modifiers, are needed to supplement standard methods of tumor control.

Abstract

Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with deep invasion, destruction of adjacent structures, recurrence and, on very rare occasions, regional and distant metastases. Mutations that occur in BCC in hedgehog (Hh) pathway genes primarily involve the genes encoding patched homolog (PTCH) and smoothened homolog (SMO). Several animal models have demonstrated the functional relevance of genetic alterations in the Hh pathway during tumorigenesis. Recently, targeted therapy has become available both commercially and in the context of human clinical trials. Interestingly, Hh pathway inhibitors not only suppress BCC progression but also promote acquired immune responses. Since immune responses are crucial for long-term tumor control, new clinical trials, such as those involving a combination of Hh inhibitors with immune modifiers, are needed to supplement standard methods of tumor control.

Statistics

Citations

11 citations in Web of Science®
11 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

27 downloads since deposited on 21 Dec 2015
18 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:May 2015
Deposited On:21 Dec 2015 13:40
Last Modified:08 Dec 2017 16:02
Publisher:Elsevier
ISSN:0923-1811
Additional Information:Invited Review Article
Publisher DOI:https://doi.org/10.1016/j.jdermsci.2015.02.007
PubMed ID:25766766

Download

Download PDF  'Hedgehog signaling in basal cell carcinoma'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 302kB
Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Download PDF  'Hedgehog signaling in basal cell carcinoma'.
Preview
Content: Supplemental Material
Filetype: PDF
Size: 967kB
Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)