Header

UZH-Logo

Maintenance Infos

Perturbing resistance: a network perspective


Levesque, Mitchell P; Dummer, Reinhard; Beerenwinkel, Niko (2015). Perturbing resistance: a network perspective. Pigment Cell & Melanoma Research, 29(1):5-7.

Abstract

The recent convergence of high-dimensional molecular datasets with small-molecule inhibitor pipelines allows for selective targeting of aberrantly regulated pathways in many cancer types. But intra-tumor heterogeneity, paradoxical activation, intrinsic or acquired therapeutic resistance, and non-linear pathway interactions confound most simple targeting strategies(Widmer et al., 2015). For instance, MAPK signaling is activated by hot-spot mutations in BRAF, which are found in about 40-50% of melanoma cases. This article is protected by copyright. All rights reserved.

Abstract

The recent convergence of high-dimensional molecular datasets with small-molecule inhibitor pipelines allows for selective targeting of aberrantly regulated pathways in many cancer types. But intra-tumor heterogeneity, paradoxical activation, intrinsic or acquired therapeutic resistance, and non-linear pathway interactions confound most simple targeting strategies(Widmer et al., 2015). For instance, MAPK signaling is activated by hot-spot mutations in BRAF, which are found in about 40-50% of melanoma cases. This article is protected by copyright. All rights reserved.

Statistics

Altmetrics

Downloads

2 downloads since deposited on 21 Dec 2015
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:16 October 2015
Deposited On:21 Dec 2015 13:49
Last Modified:16 Dec 2016 01:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1755-1471
Additional Information:News and Views; This is the peer reviewed version of the following article: [evesque, M. P., Dummer, R. and Beerenwinkel, N. (2016), Perturbing resistance: a network perspective. Pigment Cell & Melanoma Research, 29: 5–7. doi: 10.1111/pcmr.12431], which has been published in final form at [http://doi.org/10.1111/pcmr.12431]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Publisher DOI:https://doi.org/10.1111/pcmr.12431
PubMed ID:26471867

Download

Preview Icon on Download
Content: Published Version
Filetype: PDF - Registered users only
Size: 36kB
View at publisher
Preview Icon on Download
Preview
Content: Accepted Version
Filetype: PDF
Size: 41kB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations