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Expression of CD164 on malignant T Cells in Sézary syndrome


Guenova, E; Ignatova, D; Chang, Y; Contassot, E; Mehra, T; Saulite, I; Navarini, A; Mitev, V; Dummer, R; Kazakov, D V; French, L; Hötzenecker, W; Cozzio, A (2016). Expression of CD164 on malignant T Cells in Sézary syndrome. Acta Dermato-Venereologica, 96(4):464-467.

Abstract

Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by pruritic erythroderma, peripheral lymphadenopathy and the presence of malignant T cells in the blood. Unequivocal detection of malignant cells in patients with Sézary syndrome is of important diagnostic, prognostic and therapeutic value. However, no single Sézary syndrome specific cell surface marker has been identified. In a cohort of patients with Sézary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls. CD164 expression was in most cases limited to CD4+CD26– malignant T lymphocytes, unequivocally identified using flow-cytometry by the expression of a specific Vβ clone for each patient. Increased expression of CD164 may be a promising diagnostic parameter and a potential target for a CD164-linked therapeutic approach in Sézary syndrome.

Abstract

Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by pruritic erythroderma, peripheral lymphadenopathy and the presence of malignant T cells in the blood. Unequivocal detection of malignant cells in patients with Sézary syndrome is of important diagnostic, prognostic and therapeutic value. However, no single Sézary syndrome specific cell surface marker has been identified. In a cohort of patients with Sézary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls. CD164 expression was in most cases limited to CD4+CD26– malignant T lymphocytes, unequivocally identified using flow-cytometry by the expression of a specific Vβ clone for each patient. Increased expression of CD164 may be a promising diagnostic parameter and a potential target for a CD164-linked therapeutic approach in Sézary syndrome.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:21 Dec 2015 13:53
Last Modified:20 Jan 2017 00:05
Publisher:Society for the Publication of Acta Dermato-Venereologica
ISSN:0001-5555
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2340/00015555-2264
PubMed ID:26524186

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