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An overview of emerging immunotargets of genitourinary tumors


Montironi, Rodolfo; Santoni, Matteo; Cheng, Liang; Lopez-Beltran, Antonio; Massari, Francesco; Matrana, Marc R; Moch, Holger; Scarpelli, Marina (2015). An overview of emerging immunotargets of genitourinary tumors. Current Drug Targets, 17:1.

Abstract

Emerging immunotherapies targeting immune checkpoints and tumor associated antigens are leading to important clinical advances and providing a new weapon in patients with prostate (PCa) and bladder cancer (BC) and, in particular, with renal cell carcinoma (RCC). The possibility to integrate these agents in the current therapeutic scenario or genitourinary tumors, both in sequential or combined approaches, relies on a more profound comprehension of the pro-tumorigenic activity of the immune system and of the mechanisms of cancer-related immunosuppression. At this regards, neutrophils, T and B lymphocytes and tumor-associated macrophages (TAMs) are implicated in the pathogenesis, progression and development of drug resistance in genitourinary tumors. This review is an overview on the recent insights concerning the role of immune cells in this context.

Abstract

Emerging immunotherapies targeting immune checkpoints and tumor associated antigens are leading to important clinical advances and providing a new weapon in patients with prostate (PCa) and bladder cancer (BC) and, in particular, with renal cell carcinoma (RCC). The possibility to integrate these agents in the current therapeutic scenario or genitourinary tumors, both in sequential or combined approaches, relies on a more profound comprehension of the pro-tumorigenic activity of the immune system and of the mechanisms of cancer-related immunosuppression. At this regards, neutrophils, T and B lymphocytes and tumor-associated macrophages (TAMs) are implicated in the pathogenesis, progression and development of drug resistance in genitourinary tumors. This review is an overview on the recent insights concerning the role of immune cells in this context.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:9 December 2015
Deposited On:28 Dec 2015 11:49
Last Modified:05 Apr 2016 19:47
Publisher:Bentham Science Publishers Ltd.
ISSN:1389-4501
Publisher DOI:https://doi.org/10.2174/1389450117666151209144649
Official URL:http://www.eurekaselect.com/137710/article#
PubMed ID:26648079

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