Header

UZH-Logo

Maintenance Infos

Effect of Gd-DOTA on fat quantification in skeletal muscle using two-point Dixon technique - preliminary data


Filli, Lukas; Ulbrich, Erika J; Guggenberger, Roman; Boss, Andreas; Fischer, Michael A; Del Grande, Filippo; Maurer, Britta; Andreisek, Gustav (2016). Effect of Gd-DOTA on fat quantification in skeletal muscle using two-point Dixon technique - preliminary data. European Journal of Radiology, 85(1):131-5.

Abstract

PURPOSE To assess differences in fat signal fraction (FSF) in skeletal muscle as determined by two-point Dixon technique at 3T before and after application of intravenous gadoterate meglumide (Gd-DOTA). MATERIALS AND METHODS Eight patients (mean age, 50.8 years; range, 41-72 years) underwent clinical whole-body MRI at 3T for myopathic symptoms. Two-point Dixon technique based T1-weighted turbo spin-echo images were acquired before and after the administration of intravenous Gd-DOTA. On both image sets, the FSF was calculated in the gluteus medius, gluteus maximus, and quadriceps muscles bilaterally. Pre- and post-contrast FSF values were compared by linear regression, Bland-Altman plot as well as paired Student t-tests with Bonferroni correction. RESULTS The mean pre- and post-contrast FSF of included muscles were 28.7%±14.9% and 27.8%±15.1%, respectively. Linear regression indicated almost equivalent FSF estimation between pre- and post-contrast measurements (sum of squared residuals R(2), 0.92±0.04; slope, 0.97; X-intercept, -0.05; Y-intercept, +0.05). The Bland-Altman plot revealed a minimal systematical bias of the post-contrast FSF measurements of -0.87%. Paired Student t-tests did not reveal significant differences (overall p-value, 0.168). CONCLUSION Gd-DOTA does not significantly influence FSF quantification in skeletal muscle based on the two-point Dixon technique at 3T.

Abstract

PURPOSE To assess differences in fat signal fraction (FSF) in skeletal muscle as determined by two-point Dixon technique at 3T before and after application of intravenous gadoterate meglumide (Gd-DOTA). MATERIALS AND METHODS Eight patients (mean age, 50.8 years; range, 41-72 years) underwent clinical whole-body MRI at 3T for myopathic symptoms. Two-point Dixon technique based T1-weighted turbo spin-echo images were acquired before and after the administration of intravenous Gd-DOTA. On both image sets, the FSF was calculated in the gluteus medius, gluteus maximus, and quadriceps muscles bilaterally. Pre- and post-contrast FSF values were compared by linear regression, Bland-Altman plot as well as paired Student t-tests with Bonferroni correction. RESULTS The mean pre- and post-contrast FSF of included muscles were 28.7%±14.9% and 27.8%±15.1%, respectively. Linear regression indicated almost equivalent FSF estimation between pre- and post-contrast measurements (sum of squared residuals R(2), 0.92±0.04; slope, 0.97; X-intercept, -0.05; Y-intercept, +0.05). The Bland-Altman plot revealed a minimal systematical bias of the post-contrast FSF measurements of -0.87%. Paired Student t-tests did not reveal significant differences (overall p-value, 0.168). CONCLUSION Gd-DOTA does not significantly influence FSF quantification in skeletal muscle based on the two-point Dixon technique at 3T.

Statistics

Citations

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2016
Deposited On:07 Jan 2016 12:57
Last Modified:08 Dec 2017 16:38
Publisher:Elsevier
ISSN:0720-048X
Publisher DOI:https://doi.org/10.1016/j.ejrad.2015.11.007
PubMed ID:26724657

Download

Full text not available from this repository.
View at publisher