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99mTc radiolabelling of Fe3O4–Au core–shell and Au–Fe3O4dumbbell-like nanoparticles


Felber, Michael; Alberto, Roger (2015). 99mTc radiolabelling of Fe3O4–Au core–shell and Au–Fe3O4dumbbell-like nanoparticles. Nanoscale, 7(15):6653-6660.

Abstract

The development of nanoparticle-based dual-modality probes for magnetic resonance imaging (MRI) and positron emission tomography (PET) or single photon emission computed tomography (SPECT) is increasingly growing in importance. One of the most commonly used radionuclides for clinical SPECT imaging is 99mTc and the labelling of Fe3O4 nanoparticles with 99mTc was shown to be a successful strategy to obtain dual-modality imaging agents. In this work, we focus on gold containing magnetic nanomaterials. The radiolabelling of magnetic Fe3O4–Au core–shell and Fe3O4–Au dumbbell-like nanoparticles with the [99mTc(CO)3]+ fragment is described. The key elements for this 99mTc labelling approach are novel coating ligands, consisting of an anchor for the Au surface, a polyethylene glycol linker and a strong chelator for the [99mTc(CO)3]+ moiety.

Abstract

The development of nanoparticle-based dual-modality probes for magnetic resonance imaging (MRI) and positron emission tomography (PET) or single photon emission computed tomography (SPECT) is increasingly growing in importance. One of the most commonly used radionuclides for clinical SPECT imaging is 99mTc and the labelling of Fe3O4 nanoparticles with 99mTc was shown to be a successful strategy to obtain dual-modality imaging agents. In this work, we focus on gold containing magnetic nanomaterials. The radiolabelling of magnetic Fe3O4–Au core–shell and Fe3O4–Au dumbbell-like nanoparticles with the [99mTc(CO)3]+ fragment is described. The key elements for this 99mTc labelling approach are novel coating ligands, consisting of an anchor for the Au surface, a polyethylene glycol linker and a strong chelator for the [99mTc(CO)3]+ moiety.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:21 April 2015
Deposited On:14 Jan 2016 09:36
Last Modified:08 Dec 2017 16:53
Publisher:Royal Society of Chemistry
ISSN:2040-3364
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/C5NR00269A
PubMed ID:25797603

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