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Pancreatic cancer- a curable disease


Limani, Perparim; Samaras, Panagiotis; Lesurtel, Mickael; Graf, Rolf; DeOliveira, Michelle L; Petrowsky, Henrik; Clavien, Pierre-Alain (2015). Pancreatic cancer- a curable disease. Praxis, 104(9):453-60.

Abstract

Pancreatic cancer is the seventh most common cancer in Switzerland associated with a dismal prognosis. Its natural course is fatal with a 3-year survival rate below 3%. Advances in diagnostic tools, tumor staging and multimodal treatment strategies resulted in an improved 5-year survival rate of over 20%. Patients presenting with pancreatic cancer significantly benefit from a multi-disciplinary treatment strategy in an experienced hepato-pancreato-biliary center. Following a comprehensive tumor staging, surgical resection associated with adjuvant chemotherapy is still the only curative therapy option. The role of neoadjuvant chemotherapy is currently investigated in clinical trials. Patients presenting with advanced pancreatic cancer not eligible for curative treatment might benefit from inclusion into innovative clinical trials with novel treatment concepts.

Abstract

Pancreatic cancer is the seventh most common cancer in Switzerland associated with a dismal prognosis. Its natural course is fatal with a 3-year survival rate below 3%. Advances in diagnostic tools, tumor staging and multimodal treatment strategies resulted in an improved 5-year survival rate of over 20%. Patients presenting with pancreatic cancer significantly benefit from a multi-disciplinary treatment strategy in an experienced hepato-pancreato-biliary center. Following a comprehensive tumor staging, surgical resection associated with adjuvant chemotherapy is still the only curative therapy option. The role of neoadjuvant chemotherapy is currently investigated in clinical trials. Patients presenting with advanced pancreatic cancer not eligible for curative treatment might benefit from inclusion into innovative clinical trials with novel treatment concepts.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Pankreas-Chirurgie; Pankreaskarzinom; Pankreatoduodenektomie; Whipple Operation; cancer du pancréas; chirurgie pancréatique; duodenopancréatectomie; multimodal treatment; multimodale Therapie; neoadjuvant and adjuvant chemotherapies; neoadjuvante und adjuvante Chemotherapie; néoadjuvante et adjuvante chimiothérapies; pancreatic cancer; pancreatic resection; pancreaticoduodenectomy; traitement multimodal
Language:German
Date:22 April 2015
Deposited On:20 Jan 2016 13:31
Last Modified:08 Dec 2017 17:13
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/1661-8157/a001990
PubMed ID:25900693

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