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Novel bat influenza virus NS1 proteins bind double-stranded RNA and antagonize host innate immunity


Turkington, H L; Juozapaitis, M; Kerry, P S; Aydillo, T; Ayllon, J; García-Sastre, A; Schwemmle, M; Hale, B G (2015). Novel bat influenza virus NS1 proteins bind double-stranded RNA and antagonize host innate immunity. Journal of Virology, 89(20):10696-10701.

Abstract

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-competent cells but not in cells unable to establish antiviral immunity.

Abstract

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-competent cells but not in cells unable to establish antiviral immunity.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:October 2015
Deposited On:15 Feb 2016 15:15
Last Modified:05 Apr 2016 19:55
Publisher:American Society for Microbiology
ISSN:0022-538X
Funders:partially funded by the MRC-University of Glasgow Centre for Virus Research, United Kingdom, supported by CRIP (Center for Research on Influenza Pathogenesis), an NIAID-funded Center of Excellence for Influenza Research and Surveillance (CEIRS; contract HHSN272201400008C to A.G.- S.), supported by the Deutsche Forschungsgemeinschaft (grant SCHW 632/15-1 to M.S.), supported by the Swiss National Science Foundation (grant 31003A_159993 to B.G.H.)
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/JVI.01430-15
Official URL:http://jvi.asm.org/content/89/20/10696.long
PubMed ID:26246567

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