Header

UZH-Logo

Maintenance Infos

J-wave duration and slope as potential tools to discriminate between benign and malignant early repolarization


Cristoforetti, Yvonne; Biasco, Luigi; Giustetto, Carla; De Backer, Ole; Castagno, Davide; Astegiano, Piero; Ganzit, Gianpasquale; Gribaudo, Carlo Gabriele; Moccetti, Marco; Gaita, Fiorenzo (2016). J-wave duration and slope as potential tools to discriminate between benign and malignant early repolarization. Heart Rhythm, 13(3):806-811.

Abstract

Interest in early repolarization (ER) increased after the theoretical proposal1 and the clinical demonstration2 that certain electrocardiographic (ECG) patterns characterized by an elevation of the J point were associated with an increased risk of sudden cardiac death in otherwise healthy individuals. Previous studies showed that only the rare pattern characterized by a significant J-point elevation (≥2 mm) in the inferior leads associated with a slurred J wave and a horizontal/descending ST segment was associated with an increased risk of death (whether arrhythmic, from cardiac or any cause).3, 4, 5 and 6 Whether this pattern may constitute a real primary arrhythmic disorder rather than a predisposing substrate facilitating arrhythmias during ischemic episodes is still a matter of debate.
Moreover, those findings are somehow in contrast with the clinical evidence of patients presenting with idiopathic ventricular fibrillation and several different morphologies of the J wave and ST segment, questioning what is the real ECG marker able to distinguish between a malignant and a benign form of ER.
Thus, the aims of the present study were to compare the amplitude of J waves by measuring slope and duration in patients with ER syndrome and healthy athletes with ECG evidence of J-point elevation associated with J wave and to evaluate its potential role as an ECG marker of increased arrhythmic risk.

Abstract

Interest in early repolarization (ER) increased after the theoretical proposal1 and the clinical demonstration2 that certain electrocardiographic (ECG) patterns characterized by an elevation of the J point were associated with an increased risk of sudden cardiac death in otherwise healthy individuals. Previous studies showed that only the rare pattern characterized by a significant J-point elevation (≥2 mm) in the inferior leads associated with a slurred J wave and a horizontal/descending ST segment was associated with an increased risk of death (whether arrhythmic, from cardiac or any cause).3, 4, 5 and 6 Whether this pattern may constitute a real primary arrhythmic disorder rather than a predisposing substrate facilitating arrhythmias during ischemic episodes is still a matter of debate.
Moreover, those findings are somehow in contrast with the clinical evidence of patients presenting with idiopathic ventricular fibrillation and several different morphologies of the J wave and ST segment, questioning what is the real ECG marker able to distinguish between a malignant and a benign form of ER.
Thus, the aims of the present study were to compare the amplitude of J waves by measuring slope and duration in patients with ER syndrome and healthy athletes with ECG evidence of J-point elevation associated with J wave and to evaluate its potential role as an ECG marker of increased arrhythmic risk.

Statistics

Citations

2 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Cardiocentro Ticino
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:01 Feb 2016 12:29
Last Modified:05 Apr 2016 19:56
Publisher:Elsevier
ISSN:1547-5271
Publisher DOI:https://doi.org/10.1016/j.hrthm.2015.11.029
PubMed ID:26601769

Download

Full text not available from this repository.
View at publisher