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Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies


Taramasso, Maurizio; Emmert, Maximilian Y; Reser, Diana; Guidotti, Andrea; Cesarovic, Nikola; Campagnol, Marino; Addis, Alessandro; Nietlispach, Fabian; Hoerstrup, Simon P; Maisano, Francesco (2015). Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies. Journal of Cardiovascular Translational Research, 8(5):319-327.

Abstract

Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

Abstract

Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2015
Deposited On:22 Jan 2016 08:42
Last Modified:08 Dec 2017 17:37
Publisher:Springer
ISSN:1937-5387
Publisher DOI:https://doi.org/10.1007/s12265-015-9631-7
PubMed ID:25968135

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