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PYY3–36: Beyond food intake


Stadlbauer, Ulrike; Woods, Stephen C; Langhans, Wolfgang; Meyer, Urs (2015). PYY3–36: Beyond food intake. Frontiers in Neuroendocrinology, 38:1-11.

Abstract

The gastrointestinal hormone peptide tyrosine tyrosine 3–36 (PYY3–36) has attained broad recognition with respect to its involvement in energy homeostasis and the control of food intake. It is mainly secreted by distal intestinal enteroendocrine L-cells in response to eating and exerts neurally mediated, paracrine and endocrine effects on various target organs. In addition to its gastrointestinal effects, PYY3–36 has long been known to inhibit food intake. Recent closer examination of the effects of PYY3–36 revealed that this gut-derived peptide also influences a wide spectrum of behavioral and cognitive functions that are pivotal for basic processes of perception and judgment, including central information processing, salience learning, working memory, and behavioral responding to novelty. Here, we review the effects of PYY3–36 that go beyond food intake and provide a conceptual framework suggesting that several apparently unrelated behavioral actions of PYY3–36 may actually reflect different manifestations of modulating the central dopamine system.

Abstract

The gastrointestinal hormone peptide tyrosine tyrosine 3–36 (PYY3–36) has attained broad recognition with respect to its involvement in energy homeostasis and the control of food intake. It is mainly secreted by distal intestinal enteroendocrine L-cells in response to eating and exerts neurally mediated, paracrine and endocrine effects on various target organs. In addition to its gastrointestinal effects, PYY3–36 has long been known to inhibit food intake. Recent closer examination of the effects of PYY3–36 revealed that this gut-derived peptide also influences a wide spectrum of behavioral and cognitive functions that are pivotal for basic processes of perception and judgment, including central information processing, salience learning, working memory, and behavioral responding to novelty. Here, we review the effects of PYY3–36 that go beyond food intake and provide a conceptual framework suggesting that several apparently unrelated behavioral actions of PYY3–36 may actually reflect different manifestations of modulating the central dopamine system.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Dopamine; Energy homeostasis; Eating; Incentive salience; Gut peptide
Language:English
Date:2015
Deposited On:03 Feb 2016 11:25
Last Modified:08 Dec 2017 17:50
Publisher:Elsevier
ISSN:0091-3022
Publisher DOI:https://doi.org/10.1016/j.yfrne.2014.12.003
PubMed ID:25527432

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