During the year 2014, a total of 268 adverse reactions due to Swissmedic-authorized veterinary medicinal products were reported representing an increase of 7% compared to the previous year. Similar to previous years, most of the reactions reported were linked to the use of antiparasitic products (47.8%) or antiinfectives (9.3%). In 10.8% of the reports, reactions were described after the use of products acting on the hormonal system. The affected animal species were primarily dogs (182 reports), cats (58 reports), and cattle (16 reports). Additionally, 33 reports were provided within the frame of consultations with the toxicological information centre in Zurich (Tox Info Suisse). We present a short overview of the safety of COX-2 inhibitors and a series of reactions following the use of a parenteral buprenorphine solution. Finally, the vaccinovigilance program received 124 declarations following the application of various vaccines, but no detailed analysis of those reports is available.