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Naevus spilus-type congenital melanocytic naevus associated with a novel NRAS codon 61 mutation


Krengel, S; Widmer, D S; Kerl, K; Levesque, M P; Schiestl, C; Weibel, L (2016). Naevus spilus-type congenital melanocytic naevus associated with a novel NRAS codon 61 mutation. British Journal of Dermatology, 174(3):642-644.

Abstract

We recently described 17 patients with a new subtype of congenital melanocytic naevi (CMN), designated as "naevus spilus-type CMN" (1). The affected patients present with a large café-au-lait (CAL) background macule and dozens of superimposed small and medium-sized CMN. Here we report an additional case with a novel NRAS mutation (Q61L). CMN are categorized by their largest diameter (projected adult size, PAS) (2). Small CMN (SCMN, <1.5 cm PAS) and medium-sized CMN (MCMN, 1.5 - 20 cm PAS) represent rather common, solitary, slightly thickened plaques with prominent terminal hairs. This article is protected by copyright. All rights reserved.

Abstract

We recently described 17 patients with a new subtype of congenital melanocytic naevi (CMN), designated as "naevus spilus-type CMN" (1). The affected patients present with a large café-au-lait (CAL) background macule and dozens of superimposed small and medium-sized CMN. Here we report an additional case with a novel NRAS mutation (Q61L). CMN are categorized by their largest diameter (projected adult size, PAS) (2). Small CMN (SCMN, <1.5 cm PAS) and medium-sized CMN (MCMN, 1.5 - 20 cm PAS) represent rather common, solitary, slightly thickened plaques with prominent terminal hairs. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:05 Feb 2016 13:54
Last Modified:08 Dec 2017 17:53
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0007-0963
Publisher DOI:https://doi.org/10.1111/bjd.14105
PubMed ID:26302237

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