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Cognitive and neurophysiological markers of ADHD persistence and remission


Cheung, Celeste H M; Rijsdijk, Fruhling; McLoughlin, Gráinne; Brandeis, Daniel; Banaschewski, Tobias; Asherson, Philip; Kuntsi, Jonna (2016). Cognitive and neurophysiological markers of ADHD persistence and remission. British Journal of Psychiatry, 208(6):548-555.

Abstract

BackgroundAttention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals in adolescence and early adulthood.AimsTo examine the cognitive and neurophysiological processes underlying the persistence or remission of ADHD.MethodFollow-up data were obtained from 110 young people with childhood ADHD and 169 controls on cognitive, electroencephalogram frequency, event-related potential (ERP) and actigraph movement measures after 6 years.ResultsADHD persisters differed from remitters on preparation-vigilance measures (contingent negative variation, delta activity, reaction time variability and omission errors), IQ and actigraph count, but not on executive control measures of inhibition or working memory (nogo-P3 amplitudes, commission errors and digit span backwards).ConclusionsPreparation-vigilance measures were markers of remission, improving concurrently with ADHD symptoms, whereas executive control measures were not sensitive to ADHD persistence/remission. For IQ, the present and previous results combined suggest a role in moderating ADHD outcome. These findings fit with previously identified aetiological separation of the cognitive impairments in ADHD. The strongest candidates for the development of non-pharmacological interventions involving cognitive training and neurofeedback are the preparation-vigilance processes that were markers of ADHD remission.

Abstract

BackgroundAttention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals in adolescence and early adulthood.AimsTo examine the cognitive and neurophysiological processes underlying the persistence or remission of ADHD.MethodFollow-up data were obtained from 110 young people with childhood ADHD and 169 controls on cognitive, electroencephalogram frequency, event-related potential (ERP) and actigraph movement measures after 6 years.ResultsADHD persisters differed from remitters on preparation-vigilance measures (contingent negative variation, delta activity, reaction time variability and omission errors), IQ and actigraph count, but not on executive control measures of inhibition or working memory (nogo-P3 amplitudes, commission errors and digit span backwards).ConclusionsPreparation-vigilance measures were markers of remission, improving concurrently with ADHD symptoms, whereas executive control measures were not sensitive to ADHD persistence/remission. For IQ, the present and previous results combined suggest a role in moderating ADHD outcome. These findings fit with previously identified aetiological separation of the cognitive impairments in ADHD. The strongest candidates for the development of non-pharmacological interventions involving cognitive training and neurofeedback are the preparation-vigilance processes that were markers of ADHD remission.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Center for Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:05 Feb 2016 11:47
Last Modified:06 Aug 2017 07:48
Publisher:Royal College of Psychiatrists
ISSN:0007-1250
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1192/bjp.bp.114.145185
PubMed ID:26250744

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