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Hypothermia in paediatric traumatic brain injury: cons


Frey, Bernhard (2015). Hypothermia in paediatric traumatic brain injury: cons. Swiss Archives of Neurology, Psychiatry and Psychotherapy, (166):94-96.

Abstract

There is good evidence for therapeutic hypothermia as neuroprotective treatment in perinatal asphyxia and in cardiac arrest in adults. However, to date, there is no evidence in paediatric traumatic brain injury (TBI). A meta-analysis of four randomised controlled trials of hypothermia in severe paediatric TBI revealed a nonsignificant higher risk of mortality with hypothermia (risk ratio 1.45, 95% confidence interval 0.71–2.94). These patients should be kept normothermic (36–37°C). Hypothermia may be occasionally used to lower increased intracranial pressure, but arterial hypotension in the rewarming period must be avoided.

Abstract

There is good evidence for therapeutic hypothermia as neuroprotective treatment in perinatal asphyxia and in cardiac arrest in adults. However, to date, there is no evidence in paediatric traumatic brain injury (TBI). A meta-analysis of four randomised controlled trials of hypothermia in severe paediatric TBI revealed a nonsignificant higher risk of mortality with hypothermia (risk ratio 1.45, 95% confidence interval 0.71–2.94). These patients should be kept normothermic (36–37°C). Hypothermia may be occasionally used to lower increased intracranial pressure, but arterial hypotension in the rewarming period must be avoided.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:29 Jan 2016 13:50
Last Modified:29 Jan 2017 08:29
Publisher:EMH Swiss Medical Publishers
ISSN:2297-6981
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.sanp.ch/docs/sanp/2015/03/en/sanp-00324.pdf

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