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Weakly supervised cell nuclei detection and segmentation on tissue microarrays of renal clear cell carcinoma - Zurich Open Repository and Archive


Fuchs, T J; Lange, T; Wild, P J; Moch, H; Buhmann, J M (2008). Weakly supervised cell nuclei detection and segmentation on tissue microarrays of renal clear cell carcinoma. In: Rigoll, G. Pattern Recognition. Berlin, DE: Springer, 173-182.

Abstract

Renal cell carcinoma (RCC) is one of the ten most frequent malignancies in Western societies and can be diagnosed by histological tissue analysis. Current diagnostic rules rely on exact counts of cancerous cell nuclei which are manually counted by pathologists.

We propose a complete imaging pipeline for the automated analysis of tissue microarrays of renal cell cancer. At its core, the analysis system consists of a novel weakly supervised classification method, which is based on an iterative morphological algorithm and a soft-margin support vector machine. The lack of objective ground truth labels to validate the system requires the combination of expert knowledge of pathologists. Human expert annotations of more than 2000 cell nuclei from 9 different RCC patients are used to demonstrate the superior performance of the proposed algorithm over existing cell nuclei detection approaches.

Abstract

Renal cell carcinoma (RCC) is one of the ten most frequent malignancies in Western societies and can be diagnosed by histological tissue analysis. Current diagnostic rules rely on exact counts of cancerous cell nuclei which are manually counted by pathologists.

We propose a complete imaging pipeline for the automated analysis of tissue microarrays of renal cell cancer. At its core, the analysis system consists of a novel weakly supervised classification method, which is based on an iterative morphological algorithm and a soft-margin support vector machine. The lack of objective ground truth labels to validate the system requires the combination of expert knowledge of pathologists. Human expert annotations of more than 2000 cell nuclei from 9 different RCC patients are used to demonstrate the superior performance of the proposed algorithm over existing cell nuclei detection approaches.

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6 citations in Web of Science®
7 citations in Scopus®
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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:30 Jan 2009 09:50
Last Modified:05 Apr 2016 12:55
Publisher:Springer
Series Name:Lecture Notes in Computer Science
ISBN:978-3-540-69320-8
Publisher DOI:https://doi.org/10.1007/978-3-540-69321-5_18
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&con_lng=GER&func=find-b&find_code=SYS&request=005651811

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