Header

UZH-Logo

Maintenance Infos

Innate lymphocyte cells in asthma phenotypes


Ozyigit, Leyla Pur; Morita, Hideaki; Akdis, Mubeccel (2015). Innate lymphocyte cells in asthma phenotypes. Clinical and Translational Allergy, 5(23):online.

Abstract

T helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment responses, and inflammation patterns. The most-studied subgroups of asthma include TH2-associated early-onset allergic asthma, late-onset persistent eosinophilic asthma, virus-induced asthma, obesity-related asthma, and neutrophilic asthma. The recent discovery of human innate lymphoid cells capable of rapidly producing large amounts of cytokines upon activation and the mouse data pointing to an essential role for these cells in asthma models have emphasized the important role of the innate immune system in asthma and have provided a new means of better understanding asthma mechanisms and differentiating its phenotypes.

Abstract

T helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment responses, and inflammation patterns. The most-studied subgroups of asthma include TH2-associated early-onset allergic asthma, late-onset persistent eosinophilic asthma, virus-induced asthma, obesity-related asthma, and neutrophilic asthma. The recent discovery of human innate lymphoid cells capable of rapidly producing large amounts of cytokines upon activation and the mouse data pointing to an essential role for these cells in asthma models have emphasized the important role of the innate immune system in asthma and have provided a new means of better understanding asthma mechanisms and differentiating its phenotypes.

Statistics

Citations

8 citations in Web of Science®
8 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

20 downloads since deposited on 11 Feb 2016
11 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Airways; Asthma; Cytokines; Innate immunity; Phenotype
Language:English
Date:2015
Deposited On:11 Feb 2016 10:47
Last Modified:08 Dec 2017 18:24
Publisher:BioMed Central
ISSN:2045-7022
Additional Information:Erratum to this article can be found here: http://doi.org/10.1186/s13601-015-0075-6
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/s13601-015-0068-5
PubMed ID:26150907

Download

Download PDF  'Innate lymphocyte cells in asthma phenotypes'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)
Download PDF  'Innate lymphocyte cells in asthma phenotypes'.
Preview
Content: Published Version
Filetype: PDF (Erratum)
Size: 704kB
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)