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One bout of vibration exercise with vascular occlusion activates satellite cells


Aguayo, D; Mueller, S M; Boutellier, U; Auer, M; Jung, H H; Flück, M; Toigo, M (2016). One bout of vibration exercise with vascular occlusion activates satellite cells. Experimental Physiology, 101(2):295-307.

Abstract

INTRODUCTION We tested the hypothesis that whole body vibration (WBV) is insufficient to expand satellite cell (SC) numbers 24 h post exercise, whereas WBV in combination with blood flow restriction (BFR) is. METHODS Twenty-five young men were randomly assigned to one of three groups: WBV, BFR exercise or WBVBFR. SC numbers were determined from muscle biopsies of the vastus lateralis using immunohistochemistry. RESULTS SC quantity and frequency (+99.38%, P = 0.012 and +77.1%, P = 0.010, respectively) only increased in the WBVBFR group. Similar results were obtained for the quantity and frequency of myogenin+ myonuclei (+139.0%, P < 0.001 and +148.4%, P < 0.001, respectively). CONCLUSION We conclude that modification of WBV by superimposing BFR induced activation and differentiation of SC in young men, all of which had not been observed with WBV or BFR alone. These data suggest that WBVBFR might represent a novel viable anabolic stimulus. This article is protected by copyright. All rights reserved.

Abstract

INTRODUCTION We tested the hypothesis that whole body vibration (WBV) is insufficient to expand satellite cell (SC) numbers 24 h post exercise, whereas WBV in combination with blood flow restriction (BFR) is. METHODS Twenty-five young men were randomly assigned to one of three groups: WBV, BFR exercise or WBVBFR. SC numbers were determined from muscle biopsies of the vastus lateralis using immunohistochemistry. RESULTS SC quantity and frequency (+99.38%, P = 0.012 and +77.1%, P = 0.010, respectively) only increased in the WBVBFR group. Similar results were obtained for the quantity and frequency of myogenin+ myonuclei (+139.0%, P < 0.001 and +148.4%, P < 0.001, respectively). CONCLUSION We conclude that modification of WBV by superimposing BFR induced activation and differentiation of SC in young men, all of which had not been observed with WBV or BFR alone. These data suggest that WBVBFR might represent a novel viable anabolic stimulus. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:19 Feb 2016 14:27
Last Modified:01 Mar 2017 01:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0958-0670
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1113/EP085330
PubMed ID:26663352

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