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Effect of attenuation correction to regional quantification between PET/MR and PET/CT: a multi-centre study using a three-dimensional brain phantom


Teuho, Jarmo; Johansson, Jarkko; Liden, Jani; Hansen, Adam Espe; Holm, Søren; Keller, Sune Hoegild; Delso, Gaspar; Veit-Haibach, Patrick; Magota, Keiichi; Saunavaara, Virva; Tolvanen, Tuula; Teräs, Mika; Iida, Hidehiro (2016). Effect of attenuation correction to regional quantification between PET/MR and PET/CT: a multi-centre study using a three-dimensional brain phantom. Journal of Nuclear Medicine, 57(5):818-824.

Abstract

A spatial bias in brain PET/MR exists compared to PET/CT, due to MR-based attenuation correction (MRAC). We performed an evaluation between four institutions, three PET/MR and four PET/CT systems, using an anthropomorphic brain phantom. We hypothesized, that the spatial bias would be effectively minimized with CT-based attenuation correction (CTAC). METHODS Evaluation protocol was similar to quantifying changes in neurological PET studies. Regional analysis was conducted on eight anatomical VOIs in grey matter on count-normalized, resolution matched and co-registered data. On PET/MR systems, CTAC was applied as the reference method for attenuation correction. RESULTS With CTAC, visual and quantitative differences between PET/MR and PET/CT systems were minimized. Inter-system variation was +3.42 % to -3.29 % in all VOIs in PET/CTs and +2.15 % to -4.50 % in all VOIs for PET/MRs between institutions. PET/MR systems differed by +2.34 % to -2.21 %, +2.04 % to -2.08 % and -1.77 % to -5.37 % when compared to a PET/CT at each institution. The differences between PET/MR and PET/CT systems were not significant (p ≥ 0.05). CONCLUSION Visual and quantitative differences between PET/MR and PET/CT systems can be minimized by an accurate and standardized attenuation correction method. If a similar method to CTAC can be implemented for brain PET/MR imaging, there is no reason why PET/MR should not perform as well as PET/CT.

Abstract

A spatial bias in brain PET/MR exists compared to PET/CT, due to MR-based attenuation correction (MRAC). We performed an evaluation between four institutions, three PET/MR and four PET/CT systems, using an anthropomorphic brain phantom. We hypothesized, that the spatial bias would be effectively minimized with CT-based attenuation correction (CTAC). METHODS Evaluation protocol was similar to quantifying changes in neurological PET studies. Regional analysis was conducted on eight anatomical VOIs in grey matter on count-normalized, resolution matched and co-registered data. On PET/MR systems, CTAC was applied as the reference method for attenuation correction. RESULTS With CTAC, visual and quantitative differences between PET/MR and PET/CT systems were minimized. Inter-system variation was +3.42 % to -3.29 % in all VOIs in PET/CTs and +2.15 % to -4.50 % in all VOIs for PET/MRs between institutions. PET/MR systems differed by +2.34 % to -2.21 %, +2.04 % to -2.08 % and -1.77 % to -5.37 % when compared to a PET/CT at each institution. The differences between PET/MR and PET/CT systems were not significant (p ≥ 0.05). CONCLUSION Visual and quantitative differences between PET/MR and PET/CT systems can be minimized by an accurate and standardized attenuation correction method. If a similar method to CTAC can be implemented for brain PET/MR imaging, there is no reason why PET/MR should not perform as well as PET/CT.

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3 citations in Web of Science®
2 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:28 January 2016
Deposited On:23 Feb 2016 13:17
Last Modified:03 May 2016 01:03
Publisher:Society of Nuclear Medicine
ISSN:0161-5505
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2967/jnumed.115.166165
PubMed ID:26823565

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