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The potential impact of coinfection on antimicrobial chemotherapy and drug resistance


Birger, Ruthie B; Kouyos, Roger D; Cohen, Ted; Griffiths, Emily C; Huijben, Silvie; Mina, Michael; Volkova, Victoriya; Grenfell, Bryan; Metcalf, C Jessica E (2015). The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends in Microbiology, 23(9):537-44.

Abstract

Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy is rarely considered. In this review, we provide an overview of the mechanisms of interaction of coinfecting pathogens, ranging from immune modulation and resource modulation, to drug interactions. We discuss their potential implications for the evolution of resistance, providing evidence in the rare cases where it is available. Overall, our review indicates that the impact of coinfection has the potential to be considerable, suggesting that this should be taken into account when designing antimicrobial drug treatments.

Abstract

Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy is rarely considered. In this review, we provide an overview of the mechanisms of interaction of coinfecting pathogens, ranging from immune modulation and resource modulation, to drug interactions. We discuss their potential implications for the evolution of resistance, providing evidence in the rare cases where it is available. Overall, our review indicates that the impact of coinfection has the potential to be considerable, suggesting that this should be taken into account when designing antimicrobial drug treatments.

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Citations

9 citations in Web of Science®
8 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:September 2015
Deposited On:22 Feb 2016 10:46
Last Modified:05 Apr 2016 20:06
Publisher:Elsevier
ISSN:0966-842X
Publisher DOI:https://doi.org/10.1016/j.tim.2015.05.002
PubMed ID:26028590

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