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The Role of FPR1 and GPR32 in Human Inflammation


Schmid, Mattia. The Role of FPR1 and GPR32 in Human Inflammation. 2015, University of Zurich, Faculty of Medicine.

Abstract

Inflammation is the natural reaction of the body toward tissue injury or pathogen invasion with the ultimate goal to restore homeostasis. When tissue resident APCs sense a perturbation, they release an array of chemokines and signalling molecules, which in turn attract further leukocytes into the affected tissue. Neutrophils, highly specialized microbial killers, are the first cells attracted from the blood stream to counter the noxious agents. In second place, the activated environment also promotes the development of classically activated M1 macrophages in the tissue, which work in concomitance with neutropihls and sustain the inflammatory reaction.

Abstract

Inflammation is the natural reaction of the body toward tissue injury or pathogen invasion with the ultimate goal to restore homeostasis. When tissue resident APCs sense a perturbation, they release an array of chemokines and signalling molecules, which in turn attract further leukocytes into the affected tissue. Neutrophils, highly specialized microbial killers, are the first cells attracted from the blood stream to counter the noxious agents. In second place, the activated environment also promotes the development of classically activated M1 macrophages in the tissue, which work in concomitance with neutropihls and sustain the inflammatory reaction.

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Additional indexing

Item Type:Dissertation
Referees:Hennet T, Hersberger M, von Eckardstein Arnold, Halin C
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:500 Natural Sciences and mathematics
610 Medicine & health
Language:English
Date:2015
Deposited On:17 Feb 2016 13:47
Last Modified:12 Jul 2016 07:52
Number of Pages:105

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