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Modulation of T cell responses by IL-2 and IL-2 complexes


Boyman, Onur; Kolios, Antonios G A; Raeber, Miro E (2015). Modulation of T cell responses by IL-2 and IL-2 complexes. Clinical and Experimental Rheumatology, 33(4 Suppl 92):S54-S57.

Abstract

Interleukin-2 (IL-2) is a cytokine centrally involved in the regulation of immune tolerance and activation by its effects on CD4+ T regulatory (Treg) cells and cytotoxic effector lymphocytes, respectively. Due to these properties IL-2 immunotherapy has been used, as low-dose IL-2, in the treatment of autoimmune and chronic-inflammatory disorders; conversely, at high doses, IL-2 has shown efficacy in a subset of patients with metastatic cancer. Recent advances have highlighted the possibility of using improved IL-2-based therapies, such IL-2-antibody complexes (IL-2 complexes), able to selectively and potently stimulate either Treg cells or cytotoxic effector cells. This article discusses the properties and clinical implications of IL-2 and IL-2 complexes.

Abstract

Interleukin-2 (IL-2) is a cytokine centrally involved in the regulation of immune tolerance and activation by its effects on CD4+ T regulatory (Treg) cells and cytotoxic effector lymphocytes, respectively. Due to these properties IL-2 immunotherapy has been used, as low-dose IL-2, in the treatment of autoimmune and chronic-inflammatory disorders; conversely, at high doses, IL-2 has shown efficacy in a subset of patients with metastatic cancer. Recent advances have highlighted the possibility of using improved IL-2-based therapies, such IL-2-antibody complexes (IL-2 complexes), able to selectively and potently stimulate either Treg cells or cytotoxic effector cells. This article discusses the properties and clinical implications of IL-2 and IL-2 complexes.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:IL-2, CD25, CD122, CD4+, CD8+ T cell, NK cell
Language:English
Date:12 October 2015
Deposited On:26 Feb 2016 13:17
Last Modified:28 Apr 2017 03:52
Publisher:Pacini Editore SpA
ISSN:0392-856X
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.clinexprheumatol.org/article.asp?a=9877
Related URLs:http://www.clinexprheumatol.org/abstract.asp?a=9877 (Publisher)
PubMed ID:26457438

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