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Pathophysiological Toolkit; Genes to Circuits


Dölen, G; Malenka, R C; Perlmutter, J; Brose, N; Frackowiak, R; Cuthbert, B N; Diester, I; Mansuy, I M; Kroker,, K S; Boeckers, T M; Pascual-Leone, A; Guoping, F (2015). Pathophysiological Toolkit; Genes to Circuits. In: Nikolich, K; Hyman, S E. Translational Neuroscience: Toward New Therapies. Cambridge: Mit Press, 320.

Abstract

Understanding the etiology and pathophysiology of neuropsychiatric disease requires the development of new tools (ranging from evolving diagnostic strategies to biomarkers) that can address the unique challenges of neuropsychiatric disease, including the current lack of tractable interfaces between what we can learn in the clinic and the tools available using model systems in the laboratory. This chapter outlines some of these tools, addressing pitfalls and opportunities, while acknowledging the iterative nature of bridging the gaps between different levels of inquiry.

Abstract

Understanding the etiology and pathophysiology of neuropsychiatric disease requires the development of new tools (ranging from evolving diagnostic strategies to biomarkers) that can address the unique challenges of neuropsychiatric disease, including the current lack of tractable interfaces between what we can learn in the clinic and the tools available using model systems in the laboratory. This chapter outlines some of these tools, addressing pitfalls and opportunities, while acknowledging the iterative nature of bridging the gaps between different levels of inquiry.

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Additional indexing

Item Type:Book Section, not refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2015
Deposited On:29 Feb 2016 10:12
Last Modified:05 Apr 2016 20:10
Publisher:Mit Press
ISBN:978-0-262-02986-5
Related URLs:https://mitpress.mit.edu/books/translational-neuroscience (Publisher)

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