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Virus and host mechanics support membrane penetration and cell entry


Greber, Urs F (2016). Virus and host mechanics support membrane penetration and cell entry. Journal of Virology, 90(8):3802-3805.

Abstract

Viruses are quasi-inert macromolecular assemblies. Their meta-stable conformation changes during entry into cells, when chemical and mechanical host cues expose viral membrane-interacting proteins. This leads to membrane rupture or fusion, and genome uncoating. Importantly, virions tune their physical properties and enhance penetration and uncoating. For example, influenza virus softens at low pH to uncoat. Stiffness and pressure of adenovirus control uncoating and membrane penetration. Virus and host mechanics thus present new opportunities for anti-viral therapy.

Abstract

Viruses are quasi-inert macromolecular assemblies. Their meta-stable conformation changes during entry into cells, when chemical and mechanical host cues expose viral membrane-interacting proteins. This leads to membrane rupture or fusion, and genome uncoating. Importantly, virions tune their physical properties and enhance penetration and uncoating. For example, influenza virus softens at low pH to uncoat. Stiffness and pressure of adenovirus control uncoating and membrane penetration. Virus and host mechanics thus present new opportunities for anti-viral therapy.

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16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:3 February 2016
Deposited On:01 Mar 2016 17:39
Last Modified:08 Dec 2017 19:11
Publisher:American Society for Microbiology
ISSN:0022-538X
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/JVI.02568-15
PubMed ID:26842477

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