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The Astrocyte: Powerhouse and Recycling Center


Weber, Bruno; Barros, L Felipe (2015). The Astrocyte: Powerhouse and Recycling Center. Cold Spring Harbor Perspectives in Biology, 7:online.

Abstract

Brain metabolism is characterized by fuel monodependence, high-energy expenditure, autonomy from the rest of body, local recycling, and marked division of labor between cell types. Although neurons spend most of the brain's energy on signaling, astrocytes bear the brunt of the metabolic load, controlling the composition of the interstitial fluid, supplying neurons with energy substrates and precursors for biosynthesis, and recycling neurotransmitters, oxidized scavengers, and other waste products. Outstanding questions in this field are the role of oligodendrocytes, the metabolic behavior of the different subtypes of astrocytes during development and disease, and the emerging notion that metabolism may participate directly in information processing.

Abstract

Brain metabolism is characterized by fuel monodependence, high-energy expenditure, autonomy from the rest of body, local recycling, and marked division of labor between cell types. Although neurons spend most of the brain's energy on signaling, astrocytes bear the brunt of the metabolic load, controlling the composition of the interstitial fluid, supplying neurons with energy substrates and precursors for biosynthesis, and recycling neurotransmitters, oxidized scavengers, and other waste products. Outstanding questions in this field are the role of oligodendrocytes, the metabolic behavior of the different subtypes of astrocytes during development and disease, and the emerging notion that metabolism may participate directly in information processing.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2015
Deposited On:02 Mar 2016 10:13
Last Modified:08 Dec 2017 19:12
Publisher:Cold Spring Harbor Laboratory Press
ISSN:1943-0264
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1101/cshperspect.a020396
Related URLs:http://www.recherche-portal.ch/ZAD:default_scope:ebi01_prod005922503 (Library Catalogue)

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