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The potential therapeutic usefulness of targeting bk polyomavirus in prostate cancer


Provenzano, Maurizio; Keller, Etienne Xavier (2015). The potential therapeutic usefulness of targeting bk polyomavirus in prostate cancer. Chemotherapy, 5(1):1000184.

Abstract

Prostate cancer (PCa) is a slow-growing, organ-confined tumor usually accompanied with a favorable overall prognosis. Current standard-of-care chemotherapy, and recently immunotherapies, for patients suffering from this disease may prolong overall survival and improve quality of life, but they do not prevent tumor recurrence and thus are not curative. Underlying reasons are not completely understood. Recent investigations support a possible carcinogenic activity of the human BK polyomavirus (BKPyV) in the prostate. In this commentary, we envisage the development of BKPyV-related therapeutic strategies to be beneficial for individuals at risk of developing PCa.

Abstract

Prostate cancer (PCa) is a slow-growing, organ-confined tumor usually accompanied with a favorable overall prognosis. Current standard-of-care chemotherapy, and recently immunotherapies, for patients suffering from this disease may prolong overall survival and improve quality of life, but they do not prevent tumor recurrence and thus are not curative. Underlying reasons are not completely understood. Recent investigations support a possible carcinogenic activity of the human BK polyomavirus (BKPyV) in the prostate. In this commentary, we envisage the development of BKPyV-related therapeutic strategies to be beneficial for individuals at risk of developing PCa.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:4 February 2015
Deposited On:13 Apr 2016 18:58
Last Modified:08 Dec 2017 19:21
Publisher:Omics Publishing Group
ISSN:2167-7700
Publisher DOI:https://doi.org/10.4172/2167-7700.1000184
Official URL:http://www.omicsgroup.org/journals/the-potential-therapeutic-usefulness-of-targeting-bk-polyomavirus-inprostate-cancer-2167-7700-1000184.php?aid=68861

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