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Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth


Desarzens, Sébastien; Faresse, Nourdine (2016). Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth. Journal of Endocrinology, 230(1):1-11.

Abstract

The glucocorticoids bind and activate both the glucocorticoid receptor (GR) as well as the mineralocorticoid receptor (MR) in adipocytes. Despite several studies to determine the function of these two receptors in mediating glucocorticoids effects, their relative contribution in adipose tissue expansion and obesity is unclear. To investigate the effect of GR in adipose tissue function, we generated an adipocyte specific GR knockout mouse model (GRad-ko). These mice were submitted either to a standard diet or a high fat high sucrose diet. We found that adipocyte specific deletion of GR did not affect body weight gain or adipose tissue formation and distribution. However, the lack of GR in adipocyte promotes a diet-induced inflammation determined by higher pro-inflammatory genes expression and macrophage infiltration in the fat pads. Surprisingly, the adipose tissue inflammation in GRad-ko mice was not correlated with insulin resistance or dyslipidemia, but with disturbed glucose tolerance. Our data demonstrate that adipocyte specific ablation of GR in vivo may affect the adipose tissue function but not its expansion during a high calorie diet.

Abstract

The glucocorticoids bind and activate both the glucocorticoid receptor (GR) as well as the mineralocorticoid receptor (MR) in adipocytes. Despite several studies to determine the function of these two receptors in mediating glucocorticoids effects, their relative contribution in adipose tissue expansion and obesity is unclear. To investigate the effect of GR in adipose tissue function, we generated an adipocyte specific GR knockout mouse model (GRad-ko). These mice were submitted either to a standard diet or a high fat high sucrose diet. We found that adipocyte specific deletion of GR did not affect body weight gain or adipose tissue formation and distribution. However, the lack of GR in adipocyte promotes a diet-induced inflammation determined by higher pro-inflammatory genes expression and macrophage infiltration in the fat pads. Surprisingly, the adipose tissue inflammation in GRad-ko mice was not correlated with insulin resistance or dyslipidemia, but with disturbed glucose tolerance. Our data demonstrate that adipocyte specific ablation of GR in vivo may affect the adipose tissue function but not its expansion during a high calorie diet.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:22 April 2016
Deposited On:06 May 2016 16:44
Last Modified:09 Jul 2016 01:03
Publisher:Society for Endocrinology
ISSN:0022-0795
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1530/JOE-16-0121
PubMed ID:27106108

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