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Palladium-catalyzed incorporation of atmospheric CO2: efficient synthesis of functionalized oxazolidinones


García-Domínguez, Patricia; Fehr, Lorenz; Rusconi, Giulia; Nevado, Cristina (2016). Palladium-catalyzed incorporation of atmospheric CO2: efficient synthesis of functionalized oxazolidinones. Chemical Science, 7(6):3914-3918.

Abstract

Methods to incorporate atmospheric CO2 into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO2 as starting materials. These transformations, devoid of high CO2 pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation.

Abstract

Methods to incorporate atmospheric CO2 into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO2 as starting materials. These transformations, devoid of high CO2 pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2016
Deposited On:03 Jun 2016 08:32
Last Modified:03 Jun 2016 08:32
Publisher:Royal Society of Chemistry
ISSN:2041-6520
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/C6SC00419A

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