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Current State of Immune-Based Therapies for Glioblastoma


Lim, M; Weller, M; Chiocca, E A (2016). Current State of Immune-Based Therapies for Glioblastoma. Educational Book, 35:e132-e139.

Abstract

Glioblastoma is one of the most aggressive solid tumors, and, despite treatment options such as surgery, radiation, and chemotherapy, its prognosis remains grim. Novel approaches are needed to improve survival. Immunotherapy has proven efficacy for melanoma, lung cancer, and kidney cancer and is now a focus for glioblastoma. In this article, glioblastoma-mediated immunosuppression will be discussed and two exciting immune approaches, checkpoint inhibitors and viral-based therapies, will be reviewed.

Abstract

Glioblastoma is one of the most aggressive solid tumors, and, despite treatment options such as surgery, radiation, and chemotherapy, its prognosis remains grim. Novel approaches are needed to improve survival. Immunotherapy has proven efficacy for melanoma, lung cancer, and kidney cancer and is now a focus for glioblastoma. In this article, glioblastoma-mediated immunosuppression will be discussed and two exciting immune approaches, checkpoint inhibitors and viral-based therapies, will be reviewed.

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Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:10 Jun 2016 09:16
Last Modified:02 Jun 2017 09:49
Publisher:American Society of Clinical Oncology
ISSN:1548-8748
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.14694/EDBK_159084
PubMed ID:27249715

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