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$\beta$-Blockers and vascular hemodynamics in patients with peripheral arterial disease


Schlager, Oliver; Gajdosova Kovacicova, Ludmila; Senn, Oliver; Amann-Vesti, Beatrice; Wilkinson, Ian B; Jacomella, Vincenzo; Husmann, Marc (2016). $\beta$-Blockers and vascular hemodynamics in patients with peripheral arterial disease. Journal of Clinical Hypertension, 18(12):1244-1249.

Abstract

Aortic augmentation index (AIx) is a marker of central aortic pressure burden and is modulated by antihypertensive drugs. In patients with peripheral arterial disease (PAD) undergoing antihypertensive treatment, aortic pressures parameters, heart rate-adjusted augmentation index (AIx75), and unadjusted AIx were determined. The (aortic) systolic and diastolic blood pressure did not differ between PAD patients who were taking $\beta$-blockers (n=61) and those who were not taking $\beta$-blockers (n=80). In patients taking $\beta$-blockers, augmentation pressure and pulse pressure were higher than in patients who did not take $\beta$-blockers (augmentation pressure, P=.02; pulse pressure, P=.005). AIx75 was lower in PAD patients taking $\beta$-blockers than in patients not taking $\beta$-blockers (P=.04), while the AIx did not differ between PAD patients taking and not taking $\beta$-blockers. The present study demonstrates that $\beta$-blockers potentially affect markers of vascular hemodynamics in patients with PAD. Because these markers are surrogates of cardiovascular risk, further studies are warranted to clarify the impact of selective $\beta$-blocker treatment on clinical outcome in patients with PAD.

Abstract

Aortic augmentation index (AIx) is a marker of central aortic pressure burden and is modulated by antihypertensive drugs. In patients with peripheral arterial disease (PAD) undergoing antihypertensive treatment, aortic pressures parameters, heart rate-adjusted augmentation index (AIx75), and unadjusted AIx were determined. The (aortic) systolic and diastolic blood pressure did not differ between PAD patients who were taking $\beta$-blockers (n=61) and those who were not taking $\beta$-blockers (n=80). In patients taking $\beta$-blockers, augmentation pressure and pulse pressure were higher than in patients who did not take $\beta$-blockers (augmentation pressure, P=.02; pulse pressure, P=.005). AIx75 was lower in PAD patients taking $\beta$-blockers than in patients not taking $\beta$-blockers (P=.04), while the AIx did not differ between PAD patients taking and not taking $\beta$-blockers. The present study demonstrates that $\beta$-blockers potentially affect markers of vascular hemodynamics in patients with PAD. Because these markers are surrogates of cardiovascular risk, further studies are warranted to clarify the impact of selective $\beta$-blocker treatment on clinical outcome in patients with PAD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Angiology
04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:8 June 2016
Deposited On:17 Jun 2016 12:07
Last Modified:02 Feb 2018 10:05
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1524-6175
Additional Information:This is the peer reviewed version of the following article: Journal of Clinical Hypertension, 2016, 18(12):1244-1249., which has been published in final form at https://doi.org/10.1111/jch.12854. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms).
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jch.12854
PubMed ID:27279251

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