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Geschlechtsunterschiede im Krankheitsverlauf: Analyse der schweizerischen HIV-Kohortenstudie


Schmid, Margrit; Twisselmann, Wiebke; Jacquat, B J; Ledergerber, B; Battegay, M; Egger, M (1996). Geschlechtsunterschiede im Krankheitsverlauf: Analyse der schweizerischen HIV-Kohortenstudie. Swiss Medical Weekly, 126(51-52):2234-2236.

Abstract

The Swiss HIV Cohort Study (SHCS) is a prospective multicentre study of HIV-infected adults. Participants have been followed up at six-monthly intervals since 1988. The purpose of the present study was to examine sex differences in developing AIDS-defining events and in survival among participants of the SHCS (1042 women, 1507 men). A statistically significant higher risk of Pneumocystis carinii pneumonia (PCP) was evident among women. This difference was particularly pronounced in 1989 (hazard ratio 2.11, p = 0.01). Other opportunistic events and survival showed no statistically significant sex differences. The results are compatible with slower introduction of PCP prophylaxis among women. A reason for this may be that women were less likely to be enrolled in clinical trials than men. This hypothesis will be examined in a further study.

Abstract

The Swiss HIV Cohort Study (SHCS) is a prospective multicentre study of HIV-infected adults. Participants have been followed up at six-monthly intervals since 1988. The purpose of the present study was to examine sex differences in developing AIDS-defining events and in survival among participants of the SHCS (1042 women, 1507 men). A statistically significant higher risk of Pneumocystis carinii pneumonia (PCP) was evident among women. This difference was particularly pronounced in 1989 (hazard ratio 2.11, p = 0.01). Other opportunistic events and survival showed no statistically significant sex differences. The results are compatible with slower introduction of PCP prophylaxis among women. A reason for this may be that women were less likely to be enrolled in clinical trials than men. This hypothesis will be examined in a further study.

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Additional indexing

Other titles:Sex differences in disease course: analysis of the Swiss HIV cohort study
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:28 December 1996
Deposited On:24 Jun 2016 14:21
Last Modified:08 Dec 2017 19:46
Publisher:EMH Swiss Medical Publishers
ISSN:0036-7672
PubMed ID:9011933

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