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Introduction of an angle interrogated, MEMS-based, optical waveguide grating system for label-free biosensing


Kehl, Florian; Etlinger, Gerhard; Gartmann, Thomas E; Tscharner, Noe S R U; Heub, Sarah; Follonier, Stephane (2016). Introduction of an angle interrogated, MEMS-based, optical waveguide grating system for label-free biosensing. Sensors and Actuators B: Chemical, 226:135-143.

Abstract

The presented label-free optical biosensor system relies on a MEMS micro-mirror to interrogate waveguide grating regions at a high repetition rate in the kHz range by scanning the angle of the incident coherent light. The angle-tunable MEMS mirror permits an extended scanning range and offers the flexibility to measure at various wavelengths and optical powers – an interesting feature for an enhanced surface-to-bulk sensitivity ratio and extended, multiplexed sensor arrays. An excellent refractometric sensitivity with a limit of detection towards effective refractive index changes of Δneff < 2 × 10−7 and long-term stability (<10−6 min−1) is reported, as well as the capability to perform affinity measurements for large (>150 kDa) and small (<250 Da) molecules. With fully-integrated optics, electronics and fluidics, the compact, low-power and affordable sensor unit is well-suited for in situ environmental monitoring or point-of-care diagnostics.

Abstract

The presented label-free optical biosensor system relies on a MEMS micro-mirror to interrogate waveguide grating regions at a high repetition rate in the kHz range by scanning the angle of the incident coherent light. The angle-tunable MEMS mirror permits an extended scanning range and offers the flexibility to measure at various wavelengths and optical powers – an interesting feature for an enhanced surface-to-bulk sensitivity ratio and extended, multiplexed sensor arrays. An excellent refractometric sensitivity with a limit of detection towards effective refractive index changes of Δneff < 2 × 10−7 and long-term stability (<10−6 min−1) is reported, as well as the capability to perform affinity measurements for large (>150 kDa) and small (<250 Da) molecules. With fully-integrated optics, electronics and fluidics, the compact, low-power and affordable sensor unit is well-suited for in situ environmental monitoring or point-of-care diagnostics.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2016
Deposited On:18 Jul 2016 07:12
Last Modified:02 Feb 2018 10:10
Publisher:Elsevier
ISSN:0925-4005
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.snb.2015.11.072

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