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Random drug excess


Helfenstein, Ulrich; Steiner, M (1990). Random drug excess. European Journal of Drug Metabolism and Pharmacokinetics, 15(4):309-315.

Abstract

If a patient is treated in a hospital, drugs are administered at 'deterministic', known times. However, if the patient is not supervised the times of drug intake may be less 'deterministic' and less well known. It seems therefore worthwhile to make a theoretical experiment in which one assumes that drugs are applied according to a random process. In the present article it is proposed that shot noise models could be used to represent concentration curves in such situations. By means of Monte Carlo methods different measures of random drug excess are described. An included program may encourage readers to consider these methods and to perform computer experiments.

Abstract

If a patient is treated in a hospital, drugs are administered at 'deterministic', known times. However, if the patient is not supervised the times of drug intake may be less 'deterministic' and less well known. It seems therefore worthwhile to make a theoretical experiment in which one assumes that drugs are applied according to a random process. In the present article it is proposed that shot noise models could be used to represent concentration curves in such situations. By means of Monte Carlo methods different measures of random drug excess are described. An included program may encourage readers to consider these methods and to perform computer experiments.

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Citations

1 citation in Web of Science®
1 citation in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1990
Deposited On:19 Jul 2016 13:01
Last Modified:19 Jul 2016 13:01
Publisher:Springer
ISSN:0378-7966
Publisher DOI:https://doi.org/10.1007/BF03190220
PubMed ID:2088767

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