Header

UZH-Logo

Maintenance Infos

The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection


Lafranchi, Lorenzo; Sartori, Alessandro A (2016). The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection. Molecular & Cellular Oncology, 2(4):e1000696.

Abstract

DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex/cyclosome-Cdh1 (APC/C(Cdh1)) ubiquitin ligase is responsible for the timely degradation of CtBP-interacting protein (CtIP), a key DNA-end resection factor, providing a new layer of regulation of DSB repair in human cells.

Abstract

DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex/cyclosome-Cdh1 (APC/C(Cdh1)) ubiquitin ligase is responsible for the timely degradation of CtBP-interacting protein (CtIP), a key DNA-end resection factor, providing a new layer of regulation of DSB repair in human cells.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

25 downloads since deposited on 04 Aug 2016
13 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2016
Deposited On:04 Aug 2016 08:53
Last Modified:02 Feb 2018 10:12
Publisher:Taylor & Francis
ISSN:2372-3556
OA Status:Green
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/23723556.2014.1000696
PubMed ID:27308488

Download

Download PDF  'The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher
Licence: Creative Commons: Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)