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Looking beyond the genes: the interplay between signaling pathways and mechanics in the shaping and diversification of epithelial tissues


Urdy, Severine; Goudemand, Nicolas; Pantalacci, Sophie (2016). Looking beyond the genes: the interplay between signaling pathways and mechanics in the shaping and diversification of epithelial tissues. In: Orgogozo, Virginie. Genes and Evolution. Cambridge: Elsevier, 227-290.

Abstract

The core of Evo-Devo lies in the intuition that the way tissues grow during embryonic development, the way they sustain their structure and function throughout lifetime, and the way they evolve are closely linked. Epithelial tissues are ubiquitous in metazoans, covering the gut and internal branched organs, as well as the skin and its derivatives (ie, teeth). Here, we discuss in vitro, in vivo, and in silico studies on epithelial tissues to illustrate the conserved, dynamical, and complex aspects of their development. We then explore the implications of the dynamical and nonlinear nature of development on the evolution of their size and shape at the phenotypic and genetic levels. In rare cases, when the interplay between signaling and mechanics is well understood at the cell level, it is becoming clear that the structure of development leads to covariation of characters, an integration which in turn provides some predictable structure to evolutionary changes. We suggest that such nonlinear systems are prone to genetic drift, cryptic genetic variation, and context-dependent mutational effects. We argue that experimental and theoretical studies at the cell level are critical to our understanding of the phenotypic and genetic evolution of epithelial tissues, including carcinomas.

Abstract

The core of Evo-Devo lies in the intuition that the way tissues grow during embryonic development, the way they sustain their structure and function throughout lifetime, and the way they evolve are closely linked. Epithelial tissues are ubiquitous in metazoans, covering the gut and internal branched organs, as well as the skin and its derivatives (ie, teeth). Here, we discuss in vitro, in vivo, and in silico studies on epithelial tissues to illustrate the conserved, dynamical, and complex aspects of their development. We then explore the implications of the dynamical and nonlinear nature of development on the evolution of their size and shape at the phenotypic and genetic levels. In rare cases, when the interplay between signaling and mechanics is well understood at the cell level, it is becoming clear that the structure of development leads to covariation of characters, an integration which in turn provides some predictable structure to evolutionary changes. We suggest that such nonlinear systems are prone to genetic drift, cryptic genetic variation, and context-dependent mutational effects. We argue that experimental and theoretical studies at the cell level are critical to our understanding of the phenotypic and genetic evolution of epithelial tissues, including carcinomas.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
Dewey Decimal Classification:530 Physics
Uncontrolled Keywords:Morphogenesis; Evo-Devo; Morphodynamics; Simulation; Tinkering; Integration; Genetic architecture; Branching; Teeth; Cancer; Appendages; Wing; Innovation; Mechanics
Language:English
Date:5 May 2016
Deposited On:04 Aug 2016 09:19
Last Modified:05 May 2017 00:00
Publisher:Elsevier
Series Name:Current Topics in Developmental Biology
Number:119
ISSN:0070-2153
ISBN:9780124171947
Publisher DOI:https://doi.org/10.1016/bs.ctdb.2016.03.005
Related URLs:https://books.google.com/books?id=4vxZCgAAQBAJ&pg=PA227&lpg=PA227&dq=Chapter+Seven+%E2%80%93+Looking+Beyond+the+Genes:+The+Interplay+Between+Signaling+Pathways+and+Mechanics+in+the+Shaping+and+Diversification+of+Epithelial+Tissues&source=bl&ots=u8jPkvn-s2
PubMed ID:27282028

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