Header

UZH-Logo

Maintenance Infos

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward


Tachtsidis, Ilias; Scholkmann, Felix (2016). False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward. Neurophotonics, 3(3):031405.

Abstract

We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not due to neurovascular coupling. These can be misinterpreted as brain activity, i.e., "false positives" (errors caused by wrongly assigning a detected hemodynamic response to functional brain activity), or mask brain activity, i.e., "false negatives" (errors caused by wrongly assigning a not observed hemodynamic response in the presence of functional brain activity). Here, we summarize the possible physiological origins of these issues and suggest ways to avoid and remove them.

Abstract

We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not due to neurovascular coupling. These can be misinterpreted as brain activity, i.e., "false positives" (errors caused by wrongly assigning a detected hemodynamic response to functional brain activity), or mask brain activity, i.e., "false negatives" (errors caused by wrongly assigning a not observed hemodynamic response in the presence of functional brain activity). Here, we summarize the possible physiological origins of these issues and suggest ways to avoid and remove them.

Statistics

Citations

1 citation in Web of Science®
8 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

5 downloads since deposited on 31 Aug 2016
5 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2016
Deposited On:31 Aug 2016 14:10
Last Modified:09 Aug 2017 13:57
Publisher:SPIE - International Society for Optical Engineering
ISSN:2329-423X
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1117/1.NPh.3.3.031405
PubMed ID:27054143

Download

Preview Icon on Download
Preview
Content: Published Version
Filetype: PDF
Size: 743kB
View at publisher
Licence: Creative Commons: Attribution 3.0 Unported (CC BY 3.0)

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations